Heart, metabolismnmol/l
Lp(a)
Optimal
< 75 nmol/l (< 30 mg/dl); high above 125
Why
Genetically set, high in one in five people; an independent risk for heart attack and aortic stenosis that lifestyle doesn't move.
How often
Once in a lifetime is enough (genetic).
What moves it
No lifestyle lever; if high, cut the other risks (ApoB, blood pressure) harder. Targeted drugs (olpasiran, lepodisiran) are in trials.
Last reviewed: 6 September 2026
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