Cohort2025 · Nature · Eyting M et al.
Shingles vaccine cuts dementia 20% — a natural experiment
Who, how long
282,541 older adults in Wales; eligibility decided by birth date (2 Sept 1933)
What they found
Those born a week after the cut-off (eligible) had 20% fewer dementia diagnoses over 7 years — a quasi-randomised design, hence near-causal.
⚠ Caveat
Concerns the old live vaccine (Zostavax); Shingrix data are still accumulating, but point the same way.
Related in the knowledge base
Last reviewed: 6 September 2026
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