RCT2015 · NEJM · SPRINT Research Group
SPRINT: intensive blood-pressure control cuts mortality by 27%
Who, how long
9,361 high-risk hypertensive adults, 3.3 years
What they found
A <120 mmHg systolic target: –25% major cardiovascular events and –27% all-cause mortality versus <140; SPRINT-MIND found –19% mild cognitive impairment.
⚠ Caveat
More hypotension, syncope and acute kidney injury in the intensive arm; diabetics were excluded.
Related in the knowledge base
Last reviewed: 6 September 2026
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