ExperimentalExperimentalVegan form available

Fisetin (senolytic)

Cleared senescent cells and extended life 10% in mice; human trials (Mayo Clinic) are ongoing.

1/5· Mechanistic / animalEstimated monthly cost: ≈ 20 €

Dose

Trial protocol: 20 mg/kg on 2 consecutive days per month — not a recommendation.

Timing

—

⚠ Cautions

Anticoagulant effect at high doses, drug interactions; may slow wound healing.

What it is

A flavonoid (strawberries, apples) credited with senolytic action when dosed high and intermittently.

What the evidence shows

Yousefzadeh 2018: lower senescent-cell burden and longer median lifespan in old mice. Human: AFFIRM-LITE and the Mayo trials are not yet published. Don't take it outside a protocol.

Goals

Healthy years

Sources

Yousefzadeh MJ et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine (2018) ↗

Last reviewed: 6 September 2026

This site is educational and does not replace medical advice. Start any supplement or drug only after consulting a doctor or pharmacist.