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Longevity Atlas

Menopause and HRT

The loss of oestrogen between 45 and 55 accelerates bone loss, atherosclerosis and visceral fat gain. Hormone therapy started before 60 or within 10 years of menopause (transdermal oestradiol) was re-evaluated after the 2002 WHI panic: benefits mostly exceed risks.

Last reviewed: 6 September 2026

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