RCT2023 · Nature Aging / Lancet Diabetes Endocrinol · Waziry R, Kraus WE et al.
CALERIE-2: two years of calorie restriction slow biological ageing
Who, how long
218 non-obese adults (21–50), USA
What they found
An achieved 12% calorie cut over 2 years: –10% body weight, better LDL, blood pressure and insulin sensitivity, and the DunedinPACE epigenetic clock slowed 2–3%.
⚠ Caveat
Young, healthy participants; bone density dipped slightly; no direct lifespan data.
Related in the knowledge base
Last reviewed: 6 September 2026
This site is educational and does not replace medical advice. Start any supplement or drug only after consulting a doctor or pharmacist.