Mechanistic / animal2009 · Nature · Harrison DE et al.
Rapamycin extends lifespan even in old mice (ITP)
Who, how long
Genetically heterogeneous mice, from 600 days (≈60 human years)
What they found
Rapamycin in the feed: +14% (female) and +9% (male) median lifespan — the first drug to work in mammals, started late, across three labs simultaneously.
⚠ Caveat
Mice. In humans, immunosuppressive doses have known side effects; low, intermittent dosing looks safe (PEARL 2024), with no lifespan data.
Related in the knowledge base
Last reviewed: 6 September 2026
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