Medical

Rapamycin (experimental)

The only drug that extended lifespan even in old mice; in humans it improved immune response in older adults, but no longevity data exist — a research field, not a protocol.

Impact 2/52/5· Small human trialsEffort: lifestyle change

First step today

Read the rapamycin data under Research before asking anyone for a prescription.

How

Only under medical supervision, typically 3–6 mg once weekly (off-label). The PEARL trial (2024) found it safe over 48 weeks, with lean-mass gains in women.

Evidence

Harrison 2009 Nature (ITP): +9–14% lifespan in 20-month-old mice. Mannick 2014 (n=218): low-dose mTOR inhibitor improved flu-vaccine response 20% in older adults. Dog Aging Project TRIAD: ongoing.

Goals

Healthy years

Related studies

Rapamycin extends lifespan even in old mice (ITP) · 2009

Sources

Harrison DE et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) ↗
Mannick JB et al. mTOR inhibition improves immune function in the elderly. Sci Transl Med (2014) ↗

Last reviewed: 6 September 2026

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