RCT2019 · NEJM · Bhatt DL et al.
REDUCE-IT: high-dose EPA cuts cardiovascular events by 25%
Who, how long
8,179 statin-treated patients with high triglycerides, 4.9 years
What they found
4 g/day icosapent ethyl: –25% major cardiovascular events and –20% cardiovascular death.
⚠ Caveat
The placebo was mineral oil, which worsened LDL — part of the effect may stem from that. STRENGTH (mixed EPA/DHA) was neutral.
Related in the knowledge base
Last reviewed: 6 September 2026
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