RCT2021 · NEJM · Neal B et al.
SSaSS: potassium-enriched salt substitute cuts mortality 12% in 21,000 people
Who, how long
20,995 adults with prior stroke or hypertension aged 60+, 600 Chinese villages, 4.7 years
What they found
Replacing 25% of table salt with potassium chloride gave –14% stroke, –13% major cardiovascular events, –12% all-cause mortality; hyperkalaemia didn't rise.
⚠ Caveat
A high-salt (11 g/day), rural Chinese population; kidney patients were excluded — potassium can be dangerous for them.
Related in the knowledge base
Last reviewed: 6 September 2026
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