TargetedHeart, metabolismVegan form available

Vitamin K2 (MK-7)

Routes calcium into bone rather than artery walls; strong cohort and some RCT data on arterial stiffness.

3/5· Multiple human trialsEstimated monthly cost: ≈ 8 €

Dose

90–180 µg MK-7 daily, alongside D3.

Timing

With a fatty meal.

⚠ Cautions

NOT with warfarin/coumarin anticoagulants without medical advice (reduces their effect).

What it is

Menaquinone; activates osteocalcin and matrix Gla protein (MGP), the body's natural inhibitor of vascular calcification.

What the evidence shows

In the Rotterdam cohort, high K2 intake meant 50% less coronary mortality. A 3-year RCT (180 µg MK-7) slowed arterial stiffening and bone loss in postmenopausal women. No hard-endpoint RCT yet.

Goals

Heart, blood sugarHealthy years

Sources

Geleijnse JM et al. Dietary intake of menaquinone and coronary heart disease – Rotterdam Study. J Nutr (2004) ↗
Knapen MHJ et al. Menaquinone-7 supplementation improves arterial stiffness – 3-year RCT. Thromb Haemost (2015) ↗

Last reviewed: 6 September 2026

This site is educational and does not replace medical advice. Start any supplement or drug only after consulting a doctor or pharmacist.