TargetedHeart, metabolismVegan form available
TMG (betaine)
A methyl donor that lowers homocysteine and is paired with NMN/NR to replenish methyl groups; beetroot and wheat bran are the sources.
3/5· Multiple human trialsEstimated monthly cost: ≈ 6 €
Dose
500–1,500 mg daily; 500 mg alongside NMN.
Timing
Morning.
⚠ Cautions
With high LDL, check lipids after 3 months.
What it is
Trimethylglycine; drives homocysteine → methionine conversion via the folate-independent route.
What the evidence shows
Meta-analysis (5 RCTs): 4 g/day –12% homocysteine; 1.5 g already works. Small strength gains (Cholewa 2013). May slightly raise LDL at high doses.
Goals
Heart, blood sugarMuscle, strength
Last reviewed: 6 September 2026
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