Hormonesµmol/l
DHEA-S
Optimal
Age-dependent; the upper third of your age group. Over 50: men > 3, women > 2 µmol/l
Why
The adrenal's most abundant hormone, a precursor of sex hormones; it falls 80–90% from its peak at 25 to age 80 — the steepest-declining hormone. Low levels in men track with cardiovascular death (Rancho Bernardo). Supplementing it didn't improve muscle or cognition in RCTs — a marker, not a drug.
How often
Not routine; as part of a hormone panel from 45, or when chronic stress or exhaustion is suspected.
What moves it
Sleep and stress reduction (cortisol “steals” the precursor), regular exercise; DHEA pills carry hormonal side effects, endocrinologist only.
Last reviewed: 6 September 2026
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