TargetedHeart, metabolismVegan form available
Berberine
A plant alkaloid that lowered glucose and LDL in meta-analyses on a par with metformin; not “natural Ozempic”.
3/5· Multiple human trialsEstimated monthly cost: ≈ 12 €
Dose
500 mg two to three times daily with meals.
Timing
Before meals.
⚠ Cautions
Interacts with many drugs (CYP3A4, P-gp): ciclosporin, some statins, anticoagulants. Not in pregnancy. Bloating is common.
What it is
An AMPK activator that also reshapes gut flora.
What the evidence shows
Meta-analysis of 27 RCTs: HbA1c –0.7%, LDL –0.6 mmol/l in type 2 diabetes. Short (≤3 months) trials, Chinese populations; no hard endpoints.
Goals
Heart, blood sugarBody weight
Related studies
Last reviewed: 6 September 2026
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