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Resveratrol

The great hope of the 2000s; in humans dietary intake didn't lower mortality and RCTs are neutral — listed so you don't buy it.

1/5· Mechanistic / animalEstimated monthly cost: ≈ 15 €

Dose

Not recommended.

Timing

—

⚠ Cautions

High doses signalled kidney damage in myeloma patients.

What it is

A red-wine polyphenol; a sirtuin activator in mice, rapidly metabolised in humans.

What the evidence shows

InCHIANTI (n=783, 9 years): resveratrol metabolite levels did NOT associate with mortality, inflammation or heart disease. Some RCTs found it blunted exercise adaptations.

Sources

Semba RD et al. Resveratrol levels and all-cause mortality in older community-dwelling adults. JAMA Intern Med (2014) ↗

Last reviewed: 6 September 2026

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