ExperimentalExperimentalVegan form available
NMN / NR (NAD+ precursors)
nicotinamide mononucleotide · nicotinamide riboside · NAD+
Reliably raises blood NAD+; whether that translates into human health gains is open after a couple of small positive and several null RCTs.
2/5· Small human trialsEstimated monthly cost: ≈ 40 €
Dose
250–600 mg NMN or 300–1,000 mg NR daily (trial doses).
Timing
Morning.
⚠ Cautions
Theoretical concern: NAD+ also fuels tumour cells — not advised in active cancer. Expensive, unregulated market.
What it is
Precursors of the coenzyme NAD+, which falls 30–50% with age in some tissues.
What the evidence shows
Yoshino 2021 (n=25, prediabetic women, 250 mg NMN, 10 weeks): improved muscle insulin sensitivity. Yi 2023 (n=80): NMN 600–900 mg improved the 6-minute walk. Several NR RCTs (muscle, metabolism) were neutral. No hard endpoints.
Goals
Energy, fatigueHealthy years
Related studies
Sources
Last reviewed: 6 September 2026
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