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Stanford scientists discover a seafood that can reverse signs of aging

A substance found in edible sea squirts appeared to reverse several signs of aging in older mice. Plasmalogen supplements improved memory and learning, strengthened connections between brain cells, reduced inflammation, and even helped the mice grow thicker, darker hair. Researchers believe the compounds may encourage brain regeneration and protect aging synapses.

Wie viel bringt Kreatin beim Muskelaufbau?

Der Beitrag Wie viel bringt Kreatin beim Muskelaufbau? erschien zuerst auf quarks.de.

One immune switch may help drive aging across the body

Aging may be partly fueled by immune cells losing their ability to clear away damaged, inflammation-promoting cells. Blocking a single receptor restored that cleanup process in mice, reducing inflammation and helping their organs, muscles, and memory remain remarkably youthful.

Joint network analysis of non-motor symptoms and quality of life in patients with Parkinson’s disease

BackgroundNon-motor symptoms (NMS) are highly prevalent in Parkinson’s disease (PD) and are major determinants of declining quality of life (QoL), yet traditional statistical approaches are insufficient to capture the complex interactions between NMS and QoL. Network analysis offers a promising alternative for exploring these interactions.ObjectiveTo construct a joint network of non-motor symptoms (NMS) and quality of life (QoL) in patients with Parkinson’s disease (PD), identify core and bridge nodes, and inform precision nursing interventions.MethodsA convenience sample of 342 PD patients was recruited between January and June 2026 from the PD specialty outpatient clinic and neurology inpatient wards of a tertiary specialized hospital in Tianjin, and investigated using the Non-Motor Symptoms Scale (NMSS) and the Parkinson’s Disease Questionnaire-39 (PDQ-39). A joint network model was c

Ferroptosis–neuroinflammation interplay: mechanistic pathways and therapeutic opportunities in central nervous system disorders

Oxidative stress, iron dyshomeostasis, and chronic neuroinflammation are the principal mechanisms involved in the progression of central nervous system (CNS) disorders, which are a significant source of death and chronic disability worldwide. This review focuses on understanding the mechanistic relationship between ferroptosis and neuroinflammation in central nervous system (CNS) disorders, which involves the molecular mechanisms, their role in the pathogenesis of the disease, and therapeutic opportunities available. Ferroptosis is a regulated form of cell death triggered by iron-catalyzed lipid peroxidation, glutathione depletion and inactivation of glutathione peroxidase 4 (GPX4), resulting in neuronal injury. The increased generation of ROS in the cell due to the presence of excess iron catalyzes Fenton chemistry, which leads to lipid peroxidation of the cell membrane and ferroptotic

Multidimensional iron dysmetabolism and gut-brain axis interactions in restless legs syndrome: from peripheral deficiency to central dysregulation

Restless Legs Syndrome (RLS) is a sensorimotor neurological disorder characterized by an irresistible urge to move the lower limbs. Although traditional paradigms attribute its pathogenesis to peripheral iron deficiency, many clinically diagnosed patients present with normal peripheral iron indicators yet exhibit central iron homeostatic dysregulation. This discrepancy highlights a distinct decoupling between peripheral iron stores and central iron availability. The RLS-associated iron metabolic impairment is inherently a complex pathological network orchestrated by multidimensional processes, including intestinal absorption, systemic distribution, blood-brain barrier (BBB) transport, and intracellular utilization. Crucially, gut dysbiosis-induced low-grade enterogenous inflammation may activate the IL-6/hepcidin pathway, thereby sequestering systemically available iron; this mechanism r

New patent strengthens Alterity’s Parkinson’s investment

USPTO grant strengthens Alterity’s IP position and opens a path for ATH434 into Parkinson’s disease investment. Patents rarely make headlines outside the biotech trade press, but for a clinical-stage company preparing to enter a pivotal trial, a strong patent estate can matter as much as the data itself. Alterity Therapeutics has just secured one of […] The post New patent strengthens Alterity’s Parkinson’s investment appeared first on Longevity.Technology.

An Adiponectin Receptor Agonist Promotes Muscle Growth in Rats

The research community remains very interested in finding novel ways to promote muscle growth with minimal side effects. Therapies that inhibit myostatin or upregulate follistatin signaling are under development, and follistatin gene therapies have been available via medical tourism for some years. But most of the research community is focused on pharmacology, the use of small molecules to influence muscle metabolism. As an example of this type of work, researchers here report on a small molecule that mimics adiponectin signaling to promote muscle growth in rats. Skeletal muscle atrophy is a hallmark of ageing and chronic diseases, yet effective pharmacotherapies remain unavailable. Adiponectin signalling through receptors AdipoR1 and AdipoR2 regulates skeletal muscle metabolism, regeneration and oxidative capacity, but the therapeutic use of adiponectin is limited […]

Knowledge structure and frontier trends of exercise interventions for Parkinson’s disease: a bibliometric and visualized analysis

BackgroundParkinson’s disease (PD) is a progressive neurodegenerative disorder with motor and non-motor manifestations. Exercise is increasingly integrated into the management of people with PD, yet the literature spans diverse intervention modalities, outcome domains, and mechanism-related topics.ObjectiveTo characterize publication growth, global collaboration, article types, keyword networks, thematic evolution, outcome domains, and emerging research fronts in exercise intervention research for PD.MethodsEnglish-language original articles and reviews indexed in the Web of Science Core Collection and Scopus from database inception to June 15, 2026, were retrieved. After eligibility screening, cross-database merging, and removal of duplicate and bibliographically incomplete records, 6,542 publications were included. Bibliometric analyses were conducted in R version 4.5.3 using the bibli

ImmunoBrain’s immune reset shows promise in Alzheimer’s

Nature Medicine publication and late-breaking data put ImmunoBrain’s checkpoint immunotherapy and its clean safety profile in the spotlight. While much of Alzheimer’s drug development chases the disease’s hallmark proteins directly, ImmunoBrain Checkpoint is making its case from a different angle entirely: strengthening the body’s own immune system so it can help protect and repair the […] The post ImmunoBrain’s immune reset shows promise in Alzheimer’s appeared first on Longevity.Technology.

Interpretable machine learning model based on multimodal MRI radiomics for Alzheimer's disease diagnosis

ObjectiveAlzheimer's disease (AD), the most common neurodegenerative disorder, is a leading cause of cognitive impairment and dementia in older adults. This study aimed to develop an interpretable machine learning model using multimodal MRI radiomics for the diagnosis of Alzheimer's disease.Materials and methodsA total of 110 subjects (48 AD, 62 healthy control subjects) underwent 3D T1WI, DWI, and T2WI scans. Radiomics features were extracted from eight AD-related brain regions and selected using a three-step approach: variance thresholding, independent t-test, and LASSO–all conducted strictly within the training cohort. Logistic regression (LR) and random forest (RF) models were constructed for single-sequence and combined-sequence data. Model performance was evaluated using ROC analysis, calibration curves, and decision curve analysis. SHapley Additive exPlanations (SHAP) was applied

AstronauTx turns sleep into new dementia target

AstronauTx has exercised its Saniona option, advancing a sleep-focused neurodegeneration candidate toward IND-enabling studies. Sleep has become one of the most talked-about levers in longevity science, credited with everything from metabolic health to cognitive resilience. AstronauTx, a UK biotech founded by SV Health’s Dementia Discovery Fund, is now translating that interest into a drug pipeline. […] The post AstronauTx turns sleep into new dementia target appeared first on Longevity.Technology.

Short, Intense Exercise Elicits Beneficial Metabolic Changes

A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic health benefits [1]. Short and intense vs. […]

Scientists create muscle that exercises itself

Self-contracting myografts improved muscle, bone and metabolic measures in aging mice – without requiring the animals to exercise. Researchers have engineered living muscle grafts that spontaneously contract beneath the skin and appear to reproduce some of exercise’s systemic effects, improving measures of muscle function, bone health and metabolism in aging mice [1]. The work, published […] The post Scientists create muscle that exercises itself appeared first on Longevity.Technology.

This pulsating muscle graft mimics benefits of exercise

A Tougher Extracellular Matrix Strengthens Tendons in Rats

Researchers have found that an upstream promoter of two extracellular matrix proteins increases healing and strength capabilities in the tendons of rats. Tendon injuries in older people Previous research has […]

Mobility tests can tell doctors a lot about how you're aging, but there are many other factors

Hand grip strength. Balance tests. Standing up from a seated position on the floor. These physical challenges are often touted as measurements of healthy aging and even predictors of longevity.

Whole-body MRI is leaving the biohacker bubble

EHE Health’s partnership with Prenuvo brings boutique preventive scanning and reopens an old debate about who gets access to early detection. For years, whole-body MRI screening has lived in a specific cultural lane: a Silicon Valley biohacker’s routine, a wellness-influencer talking point, a service marketed to people who already track their VO2 max and sleep […] The post Whole-body MRI is leaving the biohacker bubble appeared first on Longevity.Technology.

Enveda makes ‘exercise pill’ that skips the treadmill

Drug mimics a hormone you make when you push hard at the gym – early results suggest it could help to keep weight off after stopping GLP-1s. There’s a hormone your body releases when you go hard on a run or push through a tough set at the gym. It’s called Lac-Phe, and scientists only […] The post Enveda makes ‘exercise pill’ that skips the treadmill appeared first on Longevity.Technology.

Biograph launches comprehensive women’s health program for preventive care

Biograph has launched a Women’s Health Program integrated into its Core and Black tier preventive care model to consolidate female-specific history, personalized hormone testing, comprehensive risk assessment, and tailored nutrition and exercise into longitudinal physician-led care. Research cited in the announcement found U.S. women had a life expectancy of 80 years in 2022, at least […] The post Biograph launches comprehensive women’s health program for preventive care appeared first on Longevity.Technology.

Enzymedica launches phytosome formulas for sleep, joint support

Enzymedica announced the launch of two Phytosome® formulas, Sleep & Stress Lemon Balm Phytosome and Joint & Muscle PEA Phytosome, expanding the brand’s Phytosome collection. The melatonin-free Sleep & Stress product (SRP $24.99, 60 count) is presented as a vegan, non-habit-forming option for day or night use to support relaxation and restful sleep. Joint & […] The post Enzymedica launches phytosome formulas for sleep, joint support appeared first on Longevity.Technology.

The hallmarks of skeletal muscle health

Wave Life Sciences targets fat loss without sacrificing muscle

Wave Life Sciences has moved its next-gen obesity therapy into Phase 2, aiming to tackle one of weight loss medicine’s biggest challenges. The obesity drug race has largely been defined by one question: how much weight can people lose? But a growing number of researchers are asking a different one: what kind of weight are […] The post Wave Life Sciences targets fat loss without sacrificing muscle appeared first on Longevity.Technology.

A little movement in midlife could pay off for your brain years later

Exercise and healthy blood sugar levels in midlife may help slow cognitive decline decades later. Physical activity appeared especially beneficial for Mexican American adults, suggesting that some brain-protective factors may differ across populations.

The common mistake that could make aging joints hurt more

Aging gradually wears down the cartilage and fluid that protect our joints, but avoiding movement may actually make matters worse. Exercise helps nourish cartilage, strengthens the muscles that protect joints, and can reduce osteoarthritis pain. Low-impact activities such as swimming, cycling, tai chi, yoga, and walking on varied terrain may also improve balance and mobility. Even a few minutes of the right kind of movement can make a difference.

AgelessRx wins $1m XPRIZE award to test antiaging therapy in human trial

AgelessRx has been selected as one of 10 Milestone 2 awardees in the $101 million XPRIZE Healthspan competition and awarded $1 million to advance a one-year randomized controlled trial evaluating muscle, cognitive and immune function. The company reports it completed a 90-day randomized, placebo-controlled pilot that enrolled 26 adults aged 60 to 80, with 18 […] The post AgelessRx wins $1m XPRIZE award to test antiaging therapy in human trial appeared first on Longevity.Technology.

Why menopause is a muscle-health inflection point

Silvie Health’s Thomas Schwartz-Dreyfus on why generic advice fails women 55+ and how the longevity space must adapt. The longevity field is getting better at talking about women. But when it comes to muscle, it still too often treats menopause as a lifestyle inconvenience rather than a biological inflection point. That is a costly mistake. […] The post Why menopause is a muscle-health inflection point appeared first on Longevity.Technology.

HLMS and Longevity Clinics World join forces on standards

Collaboration aims to strengthen evidence-based healthy longevity medicine through education, guidance and consistency across clinic sector. Healthy Longevity Medicine Society (HLMS) and Longevity Clinics World (LCW) have signed a Memorandum of Understanding (MOU) setting out a framework for collaboration in evidence-based Healthy Longevity Medicine worldwide. The agreement pairs HLMS’s scientific and clinical expertise with LCW’s […] The post HLMS and Longevity Clinics World join forces on standards appeared first on Longevity.Technology.

‘Judges are looking at the whole picture’

XPRIZE Healthspan Executive Director Jamie Justice on judging therapeutics, scaling interventions and navigating regulation. Twenty teams have reached the final stage of XPRIZE Healthspan, the seven-year, $101 million competition seeking therapeutics capable of restoring muscle, cognitive and immune function lost through age-related decline. Ten have also secured $1 million Milestone 2 awards; from 2026 to […] The post ‘Judges are looking at the whole picture’ appeared first on Longevity.Technology.

AstronauTx secures exclusive global rights to Saniona’s sleep-based neurological drug candidate

AstronauTx has exercised its option under the companies’ 2023 research collaboration and option agreement with Saniona to secure exclusive worldwide rights to research, develop, manufacture and commercialize therapeutic candidates arising from the collaboration. The multi-year collaboration has yielded development candidate ATX0926, which, according to the company, is expected to enter IND-enabling studies shortly. In consideration […] The post AstronauTx secures exclusive global rights to Saniona’s sleep-based neurological drug candidate appeared first on Longevity.Technology.

Niagen study links NAD+ to younger-looking muscle

New analysis suggests patented NR may influence biological aging in skeletal muscle – but researchers say the science is still unfolding. For years, the conversation around NAD+ has largely centered on energy. As levels of this essential cellular molecule decline with age, so too does the body’s ability to repair itself and maintain healthy function, […] The post Niagen study links NAD+ to younger-looking muscle appeared first on Longevity.Technology.

NADclinic, GCLS partner on longevity education

NADclinic and GCLS partner to strengthen clinician training as longevity medicine shifts from hype to healthcare. The longevity industry has spent years chasing the next breakthrough molecule, supplement or therapy. Now, one company is betting that the next competitive advantage isn’t another product – it’s better educated clinicians. NADclinic Group has announced a strategic collaboration […] The post NADclinic, GCLS partner on longevity education appeared first on Longevity.Technology.

A 42-year-old childhood obesity theory may be wrong

New research challenges the decades-old idea that children experience an “adiposity rebound” when their BMI begins rising around age 6. Although BMI returns to earlier levels, a more reliable measure showed that body fat does not rebound at all. The increase appears to come from growing muscle and lean tissue as children prepare for later growth. Researchers say this normal process has been mistakenly treated as an obesity warning sign for 42 years.

Niagen Bioscience analysis links NR to lower muscle epigenetic age

Niagen Bioscience published a peer-reviewed analysis in Aging Cell that combined skeletal muscle and blood samples from three prior clinical studies and new laboratory experiments to evaluate epigenetic age acceleration using seven established clocks, including the muscle-specific MEAT clock. According to the company, the pooled analysis found that five months of Niagen NR supplementation (1,000 […] The post Niagen Bioscience analysis links NR to lower muscle epigenetic age appeared first on Longevity.Technology.

Voyager’s single-dose gene therapy cuts tau by 75%

New six-month data strengthen the case for a one-time Alzheimer’s treatment as Voyager prepares to begin human trials later this year. What if Alzheimer’s care can be provided in the form of a single infusion given once? What if the biggest breakthrough is finally finding a reliable way to reach the brain in the first […] The post Voyager’s single-dose gene therapy cuts tau by 75% appeared first on Longevity.Technology.

Is personalized nutrition worth it?

As personalized nutrition grows, experts argue the smartest health strategy may be simple: test first, supplement second. Walk into any health store or scroll through social media for five minutes and you’ll quickly get the impression that longevity comes in capsule form. Magnesium for sleep. Creatine for strength. Vitamin D for immunity. Electrolytes because your […] The post Is personalized nutrition worth it? appeared first on Longevity.Technology.

Cognito’s sensory device shows potential to preserve brain wiring in early Alzheimer’s

Cognito Therapeutics presented exploratory cerebrospinal fluid proteomics data at AAIC 2026, according to the company. The poster, from the Phase 2 FLICKER study, evaluated daily Spectris sensory stimulation in amyloid-positive mild cognitive impairment participants and used unbiased, mass spectrometry-based proteomics to assess treatment-related changes. Investigators reported increased CSF levels of multiple HDL-like lipid transport proteins, […] The post Cognito’s sensory device shows potential to preserve brain wiring in early Alzheimer’s appeared first on Longevity.Technology.

NorthStrive tests engineered probiotic designed to protect muscle during GLP-1 weight loss

NorthStrive Biosciences, a PMGC Holdings Inc. subsidiary, plans an independent flow cytometry program to quantitatively characterize EL-22, its engineered Lactobacillus casei therapeutic candidate designed to express a latent myostatin antigen intended to help preserve muscle during weight loss treatments, including GLP-1 receptor agonists. According to the company, the FACS analysis will measure target antigen expression […] The post NorthStrive tests engineered probiotic designed to protect muscle during GLP-1 weight loss appeared first on Longevity.Technology.

Altimmune gets analyst boost as MASH data grow

A fresh analyst upgrade and encouraging clinical data are strengthening the case for pemvidutide and the future of liver health. The first wave of GLP-1 drugs changed the conversation around obesity. They helped people eat less and lose weight, but they also raised a bigger question: what comes next? For many researchers, the future isn’t […] The post Altimmune gets analyst boost as MASH data grow appeared first on Longevity.Technology.