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Rapid eye movement sleep behavior disorder as a model of early neurodegeneration: challenges for research and clinical diagnosis

Rapid eye movement (REM) sleep behavior disorder (RBD) has evolved from a descriptive parasomnia to a clinically informative model for studying early neurodegenerative processes, particularly within the spectrum of α-synucleinopathies. Defined by the loss of REM sleep atonia and the emergence of dream enactment behaviors, RBD reflects dysfunction of brainstem circuits that normally suppress motor output during dreaming. Longitudinal evidence indicates that many individuals with isolated RBD eventually develop neurodegenerative disease, most commonly Parkinson’s disease, dementia with Lewy bodies, or, less frequently, multiple system atrophy, positioning RBD among the most specific clinical markers of prodromal synucleinopathy currently recognized. Mechanistic studies suggest that RBD arises from instability within distributed REM sleep regulatory networks involving dopaminergic, noradren

"Mind-blowing" Alzheimer’s breakthrough: Two hours of sleep restored without clearing brain plaques

Scientists have uncovered an unexpected culprit behind sleep loss in Alzheimer’s disease: overactive immune cells in the brain. By temporarily removing these cells, researchers restored more than two hours of sleep per day in mice, revealing a promising new target for treatment.

Elysium launches Balance for perimenopause, menopause support

Elysium has launched Balance, a supplement aimed at perimenopause and menopause that combines Basis with S-equol and ergothioneine to target disruptive symptoms and longer-term health. According to the company, newly published research on Basis showed a significant increase in the estradiol-to-estrone ratio and reported reductions in hot flashes, poor sleep and bloating in an open-label […] The post Elysium launches Balance for perimenopause, menopause support appeared first on Longevity.Technology.

Renue by Science launches home-based health research community

Renue by Science has launched the Renue Research Community, a platform that allows consumers to take part in structured, Institutional Review Board-reviewed research from home. The company claims participants may complete validated questionnaires, contribute health information, share data from compatible wearable devices in select studies and track outcomes such as sleep, energy and physical activity […] The post Renue by Science launches home-based health research community appeared first on Longevity.Technology.

Scientists discover how deep sleep builds muscle, burns fat, and boosts the brain

Scientists have discovered a surprising two-way relationship between sleep and growth hormone, revealing how the brain carefully balances physical recovery with wakefulness. The findings could help explain why poor sleep harms metabolism and brain health, potentially opening the door to new treatments for sleep and neurological disorders.

Menopause care meets mental health via telehealth

Better U and Evernow have joined forces to pair menopause specialists with psychiatry in a nationwide telehealth service. “A woman in her forties comes in with new anxiety, broken sleep and brain fog, convinced she’s losing herself.” That’s a scene Dr Janette Leal, a psychiatrist, says she sees every week. Her next line cuts to […] The post Menopause care meets mental health via telehealth appeared first on Longevity.Technology.

Function, Google partner to connect habits with body data

Function and Google Health announced a partnership to integrate Function’s lab testing and Medical Intelligence with Google Health guidance and Google wearables. The partnership will let US users share Function lab results into the Google Health app later this fall and aims to combine wearable signals such as resting heart rate, sleep patterns, heart rate […] The post Function, Google partner to connect habits with body data appeared first on Longevity.Technology.

Magnesium is essential for health. But can supplements really help with digestion, muscle pain, anxiety and sleep? | Antiviral

Experts cite inconsistent evidence for supplementing with the essential mineral – and warn taking magnesium without a deficiency has risks Read more in the Antiviral series Dietitian Danielle Shine says her Instagram inbox was filled with questions after actor Scarlett Johansson was quoted in the Daily Mail and other publications recently saying she takes magnesium to improve her digestion and sleep. “I know that everybody is taking magnesium now. It’s so helpful,” Johansson reportedly told beauty publication Byrdie. Continue reading...

MJFF and Parkinson’s UK fund AstronauTx sleep research

London-based AstronauTx has received research funding from The Michael J. Fox Foundation for Parkinson’s Research and Parkinson’s UK to support complementary preclinical studies exploring sleep-based approaches for Parkinson’s disease. The MJFF-funded project, titled Ligand-Gated Ion Channel Modulation as a Disease-Modifying Treatment for Prodromal Synucleinopathies, will test whether AstronauTx compounds that enhance restorative sleep can reduce […] The post MJFF and Parkinson’s UK fund AstronauTx sleep research appeared first on Longevity.Technology.

Olfactory impairment and probable REM sleep behavior disorder in Parkinson’s disease: clinical relevance to the single- and dual-hit hypotheses

BackgroundRapid eye movement (REM) sleep behavior disorder (RBD) and olfactory impairment are common prodromal features of Parkinson’s disease (PD), but the implications of their coexistence remain uncertain. The dual-hit hypothesis proposes concomitant olfactory and enteric involvement, whereas the revised single-hit framework proposes predominantly brain-first or body-first routes. We examined whether probable RBD (pRBD)/anosmia-defined subgroups exhibit distinct clinical profiles.MethodsIn this cross-sectional study, 201 individuals with PD underwent olfactory, cognitive, motor, non-motor, and quality-of-life assessments. Anosmia was defined as a University of Pennsylvania Smell Identification Test score <19 and pRBD as an RBD Screening Questionnaire score ≥6 supplemented by participant and informant interviews. Multivariable models evaluated the main and interactive effects of anosmi

Distinct brain activation patterns linked to clinical symptoms during hand grasping in Parkinson's disease

ObjectiveThis study aimed to investigate the characteristics of brain functional activation during a hand grasping task in patients with Parkinson's Disease (PD) using functional near-infrared spectroscopy (fNIRS), and to further explore the clinical factors associated with the level of regional brain activation.MethodsFifty-nine PD patients were enrolled. Demographic data (age, sex, education level) and clinical characteristics (disease duration, Hoehn-Yahr stage, UPDRS-III score, side of onset, motor complications, cognitive function, activities of daily living, non-motor symptoms, and levodopa equivalent daily dose) were collected for all participants. Oxygenated hemoglobin (HbO2) signals from multiple brain regions were acquired using fNIRS during a hand grasping task. With sex, age, and disease duration as covariates, multiple linear regression analysis was used to examine the relat

Association between minimum nocturnal heart rate and cerebral small vessel disease in patients with obstructive sleep apnea

IntroductionObstructive sleep apnea (OSA) has been implicated in cerebral small vessel disease (CSVD) through mechanisms involving intermittent hypoxia, autonomic imbalance, and metabolic dysregulation, but the pathways remain insufficiently elucidated. This retrospective observational study sought to identify clinical and physiological factors associated with CSVD in adults with OSA.MethodsWe reviewed adult patients who underwent overnight polysomnography and were diagnosed with OSA at the Sleep Medicine Department of the People's Hospital of Guangxi Zhuang Autonomous Region from January 2021 to December 2023. Data collected included demographics, polysomnography, biochemical markers, and brain MRI. The primary outcome was the presence of CSVD. Multivariate logistic regression determined independent factors, and model discrimination was assessed with the area under the receiver operatin

Longitudinal associations of rest-activity rhythms with executive function, plasma biomarkers, and clinical outcomes in older adults

IntroductionDaily patterns of activity, rest, and sleep, referred to as rest–activity rhythms (RARs), can be characterized by their day-to-day regularity, within-day fragmentation, and contrast between active and rest periods across the 24-h cycle. Disruptions (e.g., irregular schedules, fragmented activity, or reduced day-night contrast) have been associated with cognitive decline among older adults. Few studies have used repeated actigraphy to distinguish person-level average RARs from visit-specific deviations.MethodsThe sample included 169 older adults without MCI or dementia at the first actigraphy visit, based on consensus clinical and neuropsychological review. Seven-day wrist actigraphy required at least three 24-h intervals with <5% missing data each; 122 participants had repeated assessments (362 observations total). RARs were characterized using three non-parametric features:

Sleep-dependent alterations in anterior cingulate cortex excitation–inhibition balance link alterations in BOLD-CSF coupling to cognitive performance in obstructive sleep apnea

ObjectiveThe roles of cortical glymphatic dysfunction and excitation-inhibition imbalance in cognitive impairment associated with obstructive sleep apnea (OSA) require further study. This study aimed to investigate sleep-related glymphatic function and neurotransmitter changes in OSA and their relationships with cognition.MethodsEighty seven participants (50 OSA, 37 controls) completed a pre-sleep MRI, followed by an overnight PSG recording, and a post-sleep MRI to assess sleep-dependent glymphatic and neurotransmitter changes. Resting-state blood-oxygen-level-dependent (BOLD) signals and cerebrospinal fluid (CSF) signals (BOLD-CSF coupling), an indirect glymphatic-related imaging proxy, were assessed in the global cortex, anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and default mode network (DMN) cortex. MRS-derived gamma-aminobutyric acid (GABA) and glutamate/glut

ŌURA defends its sleep science amid class-action lawsuit

Facing a legal challenge to its sleep-tracking claims, ŌURA is publishing the science behind its ring, with real stakes for healthy aging. Millions of people now fall asleep wearing a small titanium ring, trusting that by morning it will have quietly logged how much time they spent in deep sleep, in REM, and simply lying […] The post ŌURA defends its sleep science amid class-action lawsuit appeared first on Longevity.Technology.

Forget memory tests: Could sleep catch Alzheimer’s first?

Researchers say disrupted sleep may be one of the earliest signs of Alzheimer’s, arriving years before memory loss and reshaping drug trials. Most people chalk up a bad night’s sleep to stress, or to simply getting older. A growing body of research suggests something less comfortable: in some cases, disrupted sleep isn’t just an inconvenience […] The post Forget memory tests: Could sleep catch Alzheimer’s first? appeared first on Longevity.Technology.

Cognitive behavioral therapy may reduce biological aging among older adults with insomnia

In a new study published in The Lancet Healthy Longevity, UCLA Health researchers found that older adults who underwent cognitive behavioral therapy for insomnia were more likely to experience insomnia remission and a slower pace of biological aging than a control group that received sleep education.

Brain metabolic and network profiles characterized by comorbid depressive symptoms and sleep disturbances in Parkinson’s disease: an 18F-FDG PET study

BackgroundParkinson’s disease (PD) is a globally increasing neurodegenerative disorder. Its complex, multisystem pathophysiology extends beyond dopaminergic neuron loss and gives rise to diverse clinical manifestations. This exploratory study examined brain metabolic patterns in patients with PD and depressive symptoms (PD-Dep) or sleep disturbances (PD-SD).MethodsTwenty-eight patients with PD assessed between December 2019 and January 2024 were included. Sixteen met the HAMD threshold for PD-Dep, 21 met the PSQI threshold for PD-SD, and nine met both criteria; the cohorts were therefore overlapping symptom-defined groups. Seventeen healthy participants served as controls (HC). All participants underwent 18F-FDG PET. Voxel-wise group contrasts and exploratory AAL-based partial correlations with HAMD, PSQI, and UPDRS-III were examined.ResultsAt the prespecified liberal voxel-wise cluster-

Sleep–neuroinflammation interactions in Alzheimer’s disease: a systematic review of biomarker pathways

Although sleep disturbances are increasingly associated with Alzheimer’s disease (AD), the mechanistic interplay between sleep physiology, neuroinflammation and AD-related pathology is not fully understood. The question of whether disrupted sleep contributes to neurodegeneration or merely reflects early pathological processes is still being debated. In accordance with PRISMA-2020 guidelines, we conducted a systematic review to synthesize the current evidence linking objectively measured sleep alterations, glial activation and AD-related outcomes. A comprehensive search of PubMed, Scopus, EMBASE and Web of Science (January 2000 – June 2026) identified 40 original studies that met the predefined inclusion criteria. These studies included objective sleep assessments (polysomnography, electroencephalography, actigraphy, or experimental sleep manipulation), direct evaluations of neuroinflamma

Schlafapnoe bei Adipositas: GLP-1-Rezeptoragonisten als Ergänzung zu CPAP

Pittsburgh – Adipositas ist der wichtigste beeinflussbare Risikofaktor für obstruktive Schlafapnoe (OSA) und tritt bei etwa 60 % bis 70 % der betroffenen Personen auf. Es liegt daher nahe, von der zunehmenden Verbreitung der Glucagon-ähnlichen Peptid-1-Rezeptoragonisten (GLP-1RAs) zur Behandlung von massivem Übergewicht einen positiven Effekt auf die...[weiter lesen]

Multidimensional iron dysmetabolism and gut-brain axis interactions in restless legs syndrome: from peripheral deficiency to central dysregulation

Restless Legs Syndrome (RLS) is a sensorimotor neurological disorder characterized by an irresistible urge to move the lower limbs. Although traditional paradigms attribute its pathogenesis to peripheral iron deficiency, many clinically diagnosed patients present with normal peripheral iron indicators yet exhibit central iron homeostatic dysregulation. This discrepancy highlights a distinct decoupling between peripheral iron stores and central iron availability. The RLS-associated iron metabolic impairment is inherently a complex pathological network orchestrated by multidimensional processes, including intestinal absorption, systemic distribution, blood-brain barrier (BBB) transport, and intracellular utilization. Crucially, gut dysbiosis-induced low-grade enterogenous inflammation may activate the IL-6/hepcidin pathway, thereby sequestering systemically available iron; this mechanism r

Your sleep may be hiding an early clue to Alzheimer’s

Frequent micro-awakenings during sleep were linked to higher genetic risk for Alzheimer’s in healthy middle-aged adults who had no symptoms. The discovery raises the possibility that subtle changes during sleep could offer an early warning signal years before memory problems appear.

AstronauTx turns sleep into new dementia target

AstronauTx has exercised its Saniona option, advancing a sleep-focused neurodegeneration candidate toward IND-enabling studies. Sleep has become one of the most talked-about levers in longevity science, credited with everything from metabolic health to cognitive resilience. AstronauTx, a UK biotech founded by SV Health’s Dementia Discovery Fund, is now translating that interest into a drug pipeline. […] The post AstronauTx turns sleep into new dementia target appeared first on Longevity.Technology.

Building a health system that puts prevention first

What if your healthcare could connect the dots between your bloodwork, sleep, genetics and everyday life – before something goes wrong? What if healthcare did not begin when you got sick? That question is the center of this week’s episode of Longevity.Technology UNLOCKED, in which ahead of this year’s Longevity Investors Conference, host Phil Newman […] The post Building a health system that puts prevention first appeared first on Longevity.Technology.

Too much or too little sleep may make your body age faster

Both too little and too much sleep may be linked to faster aging throughout the body. Researchers analyzing 23 biological aging clocks found the lowest aging levels among people sleeping about 6.4 to 7.8 hours per day. Short or long sleep was also associated with numerous conditions affecting the brain, heart, lungs, metabolism, and digestive system.

This common vitamin was linked to 13% better cognitive scores

Older adults with mild cognitive impairment and sleep problems who took at least 5,000 IU of vitamin D daily scored more than 13% higher on a cognitive test than those taking none. The preliminary findings suggest vitamin D could be worth studying as a potentially modifiable factor during an early window of cognitive decline.

Whole-body MRI is leaving the biohacker bubble

EHE Health’s partnership with Prenuvo brings boutique preventive scanning and reopens an old debate about who gets access to early detection. For years, whole-body MRI screening has lived in a specific cultural lane: a Silicon Valley biohacker’s routine, a wellness-influencer talking point, a service marketed to people who already track their VO2 max and sleep […] The post Whole-body MRI is leaving the biohacker bubble appeared first on Longevity.Technology.

Enzymedica launches phytosome formulas for sleep, joint support

Enzymedica announced the launch of two Phytosome® formulas, Sleep & Stress Lemon Balm Phytosome and Joint & Muscle PEA Phytosome, expanding the brand’s Phytosome collection. The melatonin-free Sleep & Stress product (SRP $24.99, 60 count) is presented as a vegan, non-habit-forming option for day or night use to support relaxation and restful sleep. Joint & […] The post Enzymedica launches phytosome formulas for sleep, joint support appeared first on Longevity.Technology.

The association between mobility and asleep blood pressure alterations in frail and non-frail adults 80 years and older

Noncircadian BMAL1–YAP activity amplifies persistent inflammation in aged epidermis

AstronauTx secures exclusive global rights to Saniona’s sleep-based neurological drug candidate

AstronauTx has exercised its option under the companies’ 2023 research collaboration and option agreement with Saniona to secure exclusive worldwide rights to research, develop, manufacture and commercialize therapeutic candidates arising from the collaboration. The multi-year collaboration has yielded development candidate ATX0926, which, according to the company, is expected to enter IND-enabling studies shortly. In consideration […] The post AstronauTx secures exclusive global rights to Saniona’s sleep-based neurological drug candidate appeared first on Longevity.Technology.

Scientists discover why poor sleep may harm some brains more

A gene involved in the brain’s overnight cleaning system may change how strongly poor sleep affects Alzheimer’s-related brain changes. The findings point toward more personalized prevention strategies based on both genetics and sleep habits.

AI can tell if your brain is aging faster than you are

A person’s sleeping brain may reveal warning signs of dementia long before memory problems begin. Researchers used machine learning to analyze EEG recordings from about 7,000 adults and found that an older-than-expected “brain age” was tied to a sharply higher dementia risk. Every additional 10 years of brain aging raised that risk by nearly 40%.

Is personalized nutrition worth it?

As personalized nutrition grows, experts argue the smartest health strategy may be simple: test first, supplement second. Walk into any health store or scroll through social media for five minutes and you’ll quickly get the impression that longevity comes in capsule form. Magnesium for sleep. Creatine for strength. Vitamin D for immunity. Electrolytes because your […] The post Is personalized nutrition worth it? appeared first on Longevity.Technology.

Nova Capital commits $100m to back UAE longevity platform

New UAE-backed venture bets future of longevity lies not in standalone wellness brands, but in building ecosystem people never have to leave. In the wellness industry, one app tracks your sleep, another counts your steps, a smartwatch nudges you to stand, your gym has its own membership, your nutrition advice comes from somewhere else and […] The post Nova Capital commits $100m to back UAE longevity platform appeared first on Longevity.Technology.

The next frontier in Alzheimer’s trials? Sleep

Cumulus Neuroscience and Muse bring lab-grade sleep monitoring into patients’ homes, signaling a shift in how brain health may be measured. One of the biggest ironies in sleep research has been that scientists often ask people to sleep in one of the least natural places imaginable: a lab. Hooked up to wires, surrounded by unfamiliar […] The post The next frontier in Alzheimer’s trials? Sleep appeared first on Longevity.Technology.

Alzheimer’s breakthrough: Scientists restore two hours of sleep without clearing brain plaques

Researchers have uncovered a surprising culprit behind sleep loss in Alzheimer’s disease: the brain’s own immune cells. In mice with amyloid plaques, overactive microglia triggered inflammation that kept the brain from getting enough deep, restorative sleep. Temporarily removing most of these cells restored more than two hours of sleep per day, even though the plaques remained unchanged.

Dumbo Health builds a new longevity model for sleep

The startup is betting that the future of longevity isn’t another sleep score, but turning sleep data into physician-led care. Is the Function Health of sleep here? Everyone knows sleep matters. We joke about not getting enough of it, celebrate the rare eight-hour night and buy watches, rings and apps that promise to tell us […] The post Dumbo Health builds a new longevity model for sleep appeared first on Longevity.Technology.