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KI-Modell erkennt Herz-Kreislauf-Erkrankungen aus dem EKG mit wenig Trainingsbeispielen

La Jolla – Das auf Künstlicher Intelligenz (KI) beruhende System „ECG-CLIP“ könnte kardiovaskuläre Erkrankungen und klinische Ereignisse effektiver erkennen und vorhersagen als andere KI-Modelle. Das berichtet eine Arbeitsgruppe vom Scripps Research Translational Institute in La Jolla im Fachmagazin Lancet Digital Health (2026; DOI:...[weiter lesen]

Wie viel bringt Kreatin beim Muskelaufbau?

Der Beitrag Wie viel bringt Kreatin beim Muskelaufbau? erschien zuerst auf quarks.de.

Immunis wins grand prize for novel anti-aging stem cell therapy

Immunis has been awarded the Grand Prize in the National Academy of Medicine’s Healthy Longevity Global Competition for IMM01-STEM, an investigational multi-active biologic the company claims can address interconnected biological processes underlying age-related muscle and metabolic decline. The 2026 Grand Prize was open exclusively to prior Healthy Longevity Catalyst Award recipients; from 2020 to 2025 […] The post Immunis wins grand prize for novel anti-aging stem cell therapy appeared first on Longevity.Technology.

Topical Urolithin A to Improve Aged Skin Function

Mitochondria are the power plants of the cell, creating the chemical energy store molecule adenosine triphosphate used to power cellular processes. Mitochondrial function declines with age, and the research community is engaged in a variety of approaches that might at least modestly reduce this loss. The supplement urolithin A is known to improve mitochondrial function, though, and as is the case for other approaches, how exactly urolithin A accomplishes this outcome is not fully understood. Most of the ways to modestly improve mitochondrial function, ranging from exercise and calorie restriction through to NAD+ upregulation via vitamin B3 derivatives and MitoQ, may primarily function through improvements to autophagy targeted at mitochondria, improving overall mitochondrial function via improved clearance of damaged and dysfunctional mitochondria. This is by […]

Cross-cohort generalization limitations in gut microbiome-based Alzheimer’s disease classifiers: evidence from four supervised cohorts with batch-correction analysis

Gut microbiome dysbiosis has been proposed as an Alzheimer’s disease (AD) biomarker, but the transportability of microbiome classifiers across independent cohorts remains uncertain. We reprocessed five public 16S rRNA cohorts (509 samples, China, Kazakhstan, South Korea) with a common DADA2/genus-level pipeline and evaluated logistic regression and LightGBM classifiers using nested within-cohort cross-validation, leave-one-cohort-out (LOCO) transfer, pairwise transfer, permutational multivariate analysis of variance (PERMANOVA), batch adjustment, and out-of-fold SHapley Additive exPlanations (SHAP) analyses. Within four labeled cohorts, using strict training-only genus selection as the primary classifier-performance pipeline (Section 2.5.1), within-cohort area under the receiver operating characteristic curve (AUC-ROC) ranged from 0.611 to 0.996. The near-perfect Li 2019 result was stabl

Rivus to present data on new oral weight-loss drug that targets fat while saving muscle

Rivus Pharmaceuticals will present preclinical nonhuman primate and rodent data for RV-8451 at ObesityWeek 2026, with three poster presentations scheduled for 14-15 November in Washington, D.C. Poster abstracts announced by the company include a head-to-head comparison in obesity models in which RV-8451 outperforms orforglipron, a study showing RV-8451 reverses orforglipron-induced lean mass loss in a […] The post Rivus to present data on new oral weight-loss drug that targets fat while saving muscle appeared first on Longevity.Technology.

Worms live longer in cool conditions thanks to a muscle-derived molecule

Brain structure–function decoupling and neuromuscular coordination during gait and sit-to-stand in healthy aging

BackgroundAge-related decline in lower-limb motor function reflects complex interactions between central brain networks and peripheral neuromuscular coordination. This study examined how structural–functional brain organization relates to muscle coordination, intermuscular coupling, and biomechanical control during gait and sit-to-stand (STS) tasks.MethodsIn this exploratory multimodal study, thirteen healthy young adults and sixteen healthy older adults underwent resting-state fMRI, DTI, surface electromyography, motion capture, plantar pressure, and ground reaction force measurements. Muscle synergy similarity, intermuscular coherence (IMC), IMC network efficiency, center-of-pressure (COP), ground reaction force (GRF), and structure–function decoupling index (SDI) were quantified and analyzed.ResultsOlder adults exhibited lower muscle synergy similarity and reduced gait-related IMC and

Sub-$60 DEXA body scans open in Oakland

BodySpec’s new storefront targets muscle loss from GLP-1 weight loss drugs, with scans said to take about 12 minutes. Your bathroom scale is a bit of a liar by omission. It’ll tell you that you’ve lost eight pounds and keep quiet about whether those pounds were fat, muscle or something else. BodySpec’s CEO and co-founder […] The post Sub-$60 DEXA body scans open in Oakland appeared first on Longevity.Technology.

Physical exercise: a multi-target strategy for the prevention and treatment of Alzheimer’s disease

Alzheimer’s disease (AD) is a devastating age-related neurodegenerative disease characterized by irreversible cognitive dysfunction and neuronal loss. The complex pathogenesis of AD involves core proteinopathies of amyloid-β (Aβ) and tau, chronic neuroinflammation, and extensive cerebral metabolic disorders, which collectively drive progressive neuronal damage and disease deterioration. Currently, effective disease-modifying drugs for AD are still lacking, and physical exercise has been recognized as a safe and effective non-pharmacological intervention to prevent and alleviate AD pathological progression. Specifically, exercise inhibits abnormal Aβ deposition and tau hyperphosphorylation, suppresses microglial overactivation and sustained neuroinflammatory responses, and remodels cerebral metabolic homeostasis by improving glucose utilization, balancing lactate metabolism, restoring mit

Scientists discover how deep sleep builds muscle, burns fat, and boosts the brain

Scientists have discovered a surprising two-way relationship between sleep and growth hormone, revealing how the brain carefully balances physical recovery with wakefulness. The findings could help explain why poor sleep harms metabolism and brain health, potentially opening the door to new treatments for sleep and neurological disorders.

Scientists discover how exercise reverses muscle aging

Scientists have uncovered a hidden biological mechanism that helps explain how exercise can reverse some of the damage caused by muscle aging. The key is a gene called DEAF1, which becomes overactive with age and interferes with the muscles’ ability to clear damaged proteins and repair themselves. Exercise can help restore this balance, allowing older muscles to rebuild and regain strength, although the benefits may diminish when the system becomes too disrupted.

Interactions of the Gut Microbiome and Exercise in the Context of Muscle Aging Leading to Frailty

Animal studies suggest that the composition and activities of the gut microbiome are as influential on long-term health and the progression of degenerative aging as is the case for lifestyle choices such as degree of physical fitness and level of physical activity. The gut microbiome changes with age: microbial populations delivering harmful metabolites or that otherwise provoke the immune system into a state of chronic inflammation grow in number, while microbial populations delivering beneficial metabolites necessary for tissue function are reduced in number. Rejuvenation of the gut microbiome, which can be achieved via fecal microbiota transplantation from a young donor to old recipient, has been shown to improve health and extend life in aged animals. In the matters of health and aging, untangling the contribution […]

Texas imaging chain adds a brain-function test

Diagnostic Imaging Centers of Texas will pair MRI and CT with VoxNeuro’s FDA-cleared EEG software for people recovering from injuries. Texas roads supply the scale for this story. In 2024, more than 250,000 Texans were injured in motor vehicle traffic crashes, according to the Texas Department of Transportation figure cited in a 28 September announcement. […] The post Texas imaging chain adds a brain-function test appeared first on Longevity.Technology.

A 47-year study reveals the age when your body starts losing strength

A 47-year study has uncovered a surprising turning point in physical aging: fitness and strength begin declining around age 35, even among people who exercise regularly. Researchers found that this decline accelerates as people get older, but starting to exercise in adulthood can still improve physical performance.

Cognitive transfer and durability of computerised cognitive training in older adults with mild cognitive impairment: a systematic review and meta-analysis of randomised controlled trials

BackgroundComputerised cognitive training (CCT) may improve cognition in mild cognitive impairment (MCI), but whether gains transfer beyond trained processes and persist after training cessation remains uncertain. We examined immediate and sustained cognitive near transfer, cognitive far transfer, and functional far transfer.MethodsSeven databases were searched from inception to 1 July 2026. Randomised controlled trials comparing CCT with eligible controls and reporting transfer outcomes were included. Outcomes within 4 weeks after training were classified as immediate and those at least 12 weeks after cessation as sustained. Multiple eligible outcomes from the same trial were aggregated to one trial-level estimate. Random-effects models used restricted maximum likelihood and modified Knapp–Hartung inference. RoB 2 and GRADE assessed risk of bias and certainty.ResultsEleven reports from

The Hallmarks of Aging as Applied to the Vasculature Specifically

Humanity is poorly supported by its vasculature. Vascular aging is the primary cause of human mortality, giving rise to atherosclerosis, the formation of fatty plaques that narrow vessels and eventually rupture to produce a fatal blockage and thus a heart attack or stroke. The quality of the vasculature suffers in other ways along the road to old age: vessels become leaky where they should not be, allowing the passage of disruptive cells and molecules into tissues; the network of capillaries becomes less dense, reducing delivery of necessary nutrients into tissues; the smooth muscle surrounding vessels becomes less capable of constriction and relaxation, leading to a range of issues relating to blood pressure and pulsatile flow; and so forth. One can find dozens of scientific papers […]

Atrogi’s muscle pill shows early promise in 13 people

Small open-label study of ATR-258 saw fat loss, lean mass gains and better leg power, but no placebo group and just eight weeks long. Losing weight on the new wave of obesity drugs often comes with a side order of lost muscle. Studies suggest that 25–45% of the weight lost on incretin-based medicines may be […] The post Atrogi’s muscle pill shows early promise in 13 people appeared first on Longevity.Technology.

miR-128-3p Inhibition Improves Muscle Mass and Function in Aged Mice

That the calorie restriction imposed by GLP-1 receptor agonists induces loss of muscle mass has proved a boon for research into ways to address the loss of muscle mass that occurs with age, contributing to frailty. Suddenly a relatively large amount of funding and industry attention is available for programs that might result in a drug to prevent muscle loss in GLP-1 receptor agonist patients, and most of those options can at least in principle be used to treat age-related muscle loss. Here, researchers demonstrate a novel approach to inducing muscle growth in aged mice, by inhibiting a relevant microRNA; the technology is developed by Elenae Therapeutics which, as is usual, targets more severe and less common indications at the outset, such as improving outcomes […]

IBIO-610 combined with semaglutide targets fat loss while protecting muscle

IBio’s eight-week obese nonhuman primate study (n=6 per group) found lean mass comprised 6% of weight lost with IBIO-610 plus semaglutide versus 22% with semaglutide alone. The company claims additional analysis showed fat accounted for 93% of weight loss with a single dose of IBIO-610 plus twice-weekly semaglutide compared with 77% for semaglutide alone. IBio […] The post IBIO-610 combined with semaglutide targets fat loss while protecting muscle appeared first on Longevity.Technology.

Scientists discover a surprising paradox in how our cells age

Scientists have discovered that the body's cellular recycling system behaves very differently during aging than previously believed, with higher activity sometimes linked to worse physical health. A small study suggests that even gentle exercise could help restore more youthful cellular recycling patterns in older adults.

Fight Aging! Newsletter, October 12th 2026

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please visit: https://www.fightaging.org/newsletter/. To unsubscribe, send email or reply to this email at newsletter@fightaging.org with "unsubscribe" in the subject or body. Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Fat Infiltration into Muscle Tissue as a Biomarker of Aging Reduced Cardiolipin Levels as a Cause of Mitochondrial Dysfunction and

AgelessRx introduces GHK-Cu Cream for age-related skin repair

AgelessRx has launched GHK-Cu Cream, a prescription copper peptide cream designed to support tissue repair and renewal that changes with age. According to the company, the formulation is offered in clinician-guided concentrations of 0.5% and 3% to allow providers to select a starting strength based on patient history, treatment area and tolerance. The company claims […] The post AgelessRx introduces GHK-Cu Cream for age-related skin repair appeared first on Longevity.Technology.

Only one workout helped older adults lose fat and keep muscle

A six-month study suggests that high-intensity interval training (HIIT) may offer older adults a powerful advantage: losing body fat while keeping their muscle. Unlike moderate-intensity workouts, which led to a small loss of lean muscle, HIIT preserved it while also improving body composition around the waist.

Exercise Slows Epigenetic Aging and Improves Cognitive Function in Cancer Survivors

Cancer survivors who underwent chemotherapy or radiotherapy in the course of putting their cancer into remission have been shown to exhibit an increased burden of senescent cells relative to healthy peers. This is thought to explain the observed reduction in life expectancy and increased odds of unrelated cancers in cancer survivors. In general, these individuals are aging more rapidly than would be the case with a lesser burden of senescent cells, as these errant cells generate inflammatory signaling that is disruptive to tissue structure and function throughout the body. Evidence suggests that interventions like exercise that upregulate the cellular maintenance processes of autophagy can reduce the pace at which cells become senescent, and perhaps help to spur greater immune mediated clearance of lingering senescent cells […]

Pyroptosis: a potential target and research progress of exercise in ameliorating Alzheimer’s disease pathology

Alzheimer’s disease (AD), a debilitating neurodegenerative disorder that severely threatens elderly health, is clinically manifested as cognitive decline and driven by core pathological hallmarks including amyloid-beta (Aβ) deposition, tau hyperphosphorylation, and chronic neuroinflammation. Recent studies have indicated that its pathophysiological process is closely associated with pyroptosis, and excessive activation of pyroptosis drives a vicious cycle of amplified inflammation and neuronal injury. Although accumulating evidence suggests that exercise serves as an effective non-pharmacological intervention to suppress pyroptosis and alleviate AD, the intrinsic interactive mechanisms among exercise, pyroptosis and the pathological progression of AD remain incompletely elucidated. Therefore, this review systematically summarizes the functional mechanisms of pyroptosis in the pathologica

Reduced Cardiolipin Levels as a Cause of Mitochondrial Dysfunction and Muscle Remodeling

Hundreds of mitochondria in every cell work to produce adenosine triphosphate (ATP), a chemical energy store molecule needed to power cell activities. Mitochondria evolved from symbiotic bacteria, and are now fully integrated as components of the cell, with much of their original DNA moved into the cell nucleus. Mitochondria become dysfunctional with age, reducing their production of ATP, increasing oxidative byproducts, and causing maladaptive inflammatory reactions. This is an important contribution to the disruption of cell and tissue function that takes place in aged tissues. Unfortunately, mitochondrial dysfunction, while well established and readily measured, is also enormously complex and incompletely understood. Many different contributing mechanisms are plausible, but it is a challenge to determine which of them are more or less important than the others. […]

Association of statin use with reduced risk of Alzheimer’s disease: findings in UK Biobank

BackgroundPrevious studies on the association between statin use and the risk of Alzheimer’s disease (AD) have yielded inconsistent results. This study, based on the large-scale UK Biobank cohort, evaluates the relationship between statin use and the risk of new-onset AD, survival in patients with AD, and cognitive function.MethodsThis study included 502,401 participants with a median follow-up of 9.24 years. The association between statin use and the risk of AD was analyzed using Cox proportional hazards models, logistic regression, and propensity score matching. The robustness of the results was assessed through internal validation using training and validation groups, as well as subgroup analyses.ResultsA total of 975 new cases of AD were recorded. Multivariate Cox regression analysis showed that statin use was associated with a reduced risk of AD (HR = 0.72, 95% CI: 0.52–0.98; p < 0.

Fat Infiltration into Muscle Tissue as a Biomarker of Aging

An important goal in the research community is to build a robust measure of biological age, the burden of age-related damage and dysfunction contributing to disease and mortality, that can be used to rapidly assess the quality of any potential intervention to slow or reverse aging. One of the reasons why the longevity field moves slowly is that, in the absence of a robust measure of biological age, it takes a long time to assess any given therapy by running life span studies in mice, and repeating such studies in humans is infeasible. So there is relatively little drive to compare, contrast, and optimize approaches shown to slow or reverse aging in laboratory species. One might hope that a robust measure of biological age would […]

Genflow gene therapy nudges aging clock in dogs

Aged beagle data hint at lower biological age and preliminary muscle changes with SIRT6c treatment, although key readouts remain ahead. Genflow Biosciences has presented interim results from its SLAB (Sarcopenia and Longevity in Aged Beagles) study suggesting its SIRT6c gene therapy may influence biological aging in already-aged dogs, with early signals spanning DNA methylation and […] The post Genflow gene therapy nudges aging clock in dogs appeared first on Longevity.Technology.

BodySpec opens body composition scanning storefront in downtown Oakland

BodySpec opened a storefront in downtown Oakland, California, on Sept. 30, 2026. The location offers medical-grade dual-energy X-ray absorptiometry body composition scans that measure body fat, visceral fat, lean muscle mass and bone density in about 12 minutes. Scans are offered for less than $60 and include a comprehensive digital dashboard and access to a […] The post BodySpec opens body composition scanning storefront in downtown Oakland appeared first on Longevity.Technology.

Atrogi reports early trial success for drug that cuts fat while building muscle

Atrogi announced positive human data for ATR-258 from an 8-week, investigator-initiated, open-label, single-arm study in 13 overweight or obese subjects. ATR-258 is a first-in-class, oral GRK2-biased β2-adrenergic modulator designed to target skeletal muscle and to improve body composition and muscle function. The company reports ATR-258 was well tolerated across three ascending dose levels and was […] The post Atrogi reports early trial success for drug that cuts fat while building muscle appeared first on Longevity.Technology.

Dual-scale assessment of motor dysfunction in older adults with locomotor dysfunction and its association with gait and muscle activation

ObjectiveThis study examined the reliability and validity of a combined 25-question geriatric locomotive function scale (GLFS-25) and Locomotion Dysfunction Grade scale (LDG) classification protocol in older adults with locomotor dysfunction, and explored which objective gait and muscle activation parameters were most strongly associated with GLFS-25 scores.MethodsThe GLFS-25 and LDG were used to assess 289 older adults with locomotor dysfunction, of whom 60 underwent gait analysis and surface electromyography (sEMG).ResultsReliability analysis yielded a Cronbach’s α of 0.702 for the GLFS-25, indicating acceptable but modest internal consistency. Exploratory factor analysis extracted nine factors, accounting for 55.193% of the cumulative variance. Confirmatory factor analysis showed X2/df = 1.424, RMSEA = 0.038 (90% CI: 0.000–0.060), and SRMR = 0.055, indicating acceptable fit; however,

Even one strength training session a week could make a difference

Strength training may be one of the most powerful tools for staying independent as you age. Age related muscle loss, known as sarcopenia, can make everyday tasks harder while increasing the risk of falls, fractures, and loss of mobility. Research shows that resistance exercises such as squats, weights, resistance bands, and even body weight movements can preserve or rebuild strength, and surprisingly, even one session a week can produce meaningful benefits.

Longitudinal changes in hand dominance and manual dexterity in normal aging and mild cognitive impairment (MCI): a kinematic study

IntroductionDecrements on hand dominance in older populations, including neurodegenerative conditions, have been reported cross-sectionally. At present, no longitudinal research on this issue is available.MethodsTo address this research gap, we conducted a detailed kinematic analysis of unimanual movements of the dominant and non-dominant hands in 16 patients with mild cognitive impairment (MCI) (M age = 69.3 yrs) and 20 healthy controls (HC) (M age = 69.9 yrs) at two points in time with an averaged time interval of 4.5 years between evaluations (3.5 yrs. for HC; 5.35 yrs. for MCI). The inserting pins task from the Purdue Pegboard Test was recorded with a 2D motion capture system (Vicon Motus). Linear and angular velocities, as well as path length together with their coefficients of variation were calculated for specific actions (i.e., reaching, grasping, transport and inserting) and lat

Cardiorespiratory fitness is associated with cerebral oxygen extraction in Alzheimer’s disease

Cardiorespiratory fitness (CRF) is a modifiable determinant of brain health and has been associated with greater brain volume, improved cognition, and reduced dementia risk. However, whether CRF influences cerebral oxygen extraction fraction (OEF), a marker reflecting the balance between cerebral oxygen delivery and metabolic demand, remains poorly understood in aging and Alzheimer’s disease (AD). We performed a secondary analysis of the Acute Exercise Response on Brain Imaging and Cognition (AEROBIC) study to investigate relationships among CRF, cerebral blood flow (CBF), and OEF in cognitively healthy older adults (CH) and individuals with AD. Multivariable linear regression demonstrated that higher CRF was independently associated with lower OEF. A significant CRF × diagnosis interaction indicated that this relationship was present in AD but not CH. Across the full cohort, higher CBF

The Geomagnetic Field Influences Mitochondrial Function in Complex Ways

It is well known that electromagnetic fields affect cellular biochemistry, but the interactions are complex enough that electromagnetic therapies have yet to emerge in any robust way. It remains challenging to replicate and explain benefits arising in some studies from even long-standing forms of electromagnetic therapy, such as the use of pulsed electromagnetic field devices. While in principle carefully sculpted electromagnetic fields can enhance or impede specific biochemical reactions occurring in cells, in practice this line of development remains largely unexplored. Here, by shielding flies with and without mutations affecting mitochondrial function from the natural geomagnetic field, reducing field strength to a very low level, researchers show that the geomagnetic field meaningfully affects mitochondrial function, and thus longevity. The effects are clearly complex and circumstan

Creatine may help build muscle even without exercise, researchers find

Creatine helped middle-aged adults gain muscle and strength even without a structured workout program in a new 12-week study. When combined with exercise and a calorie-reduced diet, it produced even greater strength gains while helping participants add lean tissue and lose fat. Researchers say the results strengthen the case for creatine as a potentially useful tool for maintaining muscle with age.

Exercise program supports better attention and slows biological aging in breast cancer survivors

One in three breast cancer survivors will experience cognitive problems, which can include difficulties with attention, memory, processing speed and other aspects of thinking. Researchers believe these problems can arise from a combination of treatment effects, inflammation, hormonal changes, fatigue and stress. They may persist after treatment and affect everyday activities and quality of life.

Multicomponent training versus elastic-band training for improving global cognition and executive function in older women: a randomized controlled trial

ObjectiveTo compare the effects of multicomponent training (MCT) and elastic-band training (EBT) on global cognition and executive function in older women.MethodsThis single-blind, parallel-group randomized controlled trial was conducted over 16 weeks and included two supervised 60-min sessions per week. Twenty-six older women were randomly assigned to either the MCT group (n = 13) or the EBT group (n = 13). Cognitive outcomes included global cognition assessed with the Montreal Cognitive Assessment (MoCA), processing speed and visual attention assessed with the Trail Making Test Part A (TMT-A), and executive function assessed with the Trail Making Test Part B (TMT-B). Linear mixed-effects models were used to evaluate group, time, and group × time effects while adjusting for age and education. TMT-B was predefined as the primary executive function outcome.ResultsA significant group × tim