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Kuratierte News
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Gürtelrose-Impfung senkt Demenzrisiko einer Studie zufolge um 24 Prozent
Eine Studie mit über 500.000 US-Bürgern ab 66 Jahren, die in Pflegeeinrichtungen aufgenommen wurden, zeigt: Geimpfte mit dem Gürtelrose-Impfstoff Shingrix hatten ein um 24 Prozent geringeres Demenzrisiko über vier Jahre als Ungeimpfte. Laut Studienautorin Kaley Hayes von der Brown University wäre rechnerisch bei jedem 17. Geimpften ein Demenzfall verhindert worden. Frühere Studien zu einem älteren Gürtelrose-Impfstoff kamen zu ähnlichen Ergebnissen.
Ebola-Ausbruch im Kongo trifft besonders Kinder
Drei Minuten Sprinten verändern den Blutkreislauf stärker als 90 Minuten moderates Training
Aldi und Lidl entdecken Pilates und Padel als Geschäft
Sportwissenschaftlerin: Beweglichkeitstraining wird im Alter wichtiger
Ozempic aktiviert im Gehirn unerwartet Hunger-Neuronen
Fünf Minuten am Tag: Wie kleine Gewohnheiten die Hirngesundheit fördern
Salmonellen stecken in immer mehr Lebensmitteln
Ernährungsexperten warnen vor weniger Protein für längeres Leben
KI-entwickelte „Intrabodies“ könnten neue Therapien gegen Alzheimer und Parkinson ermöglichen
Studie: Kaffeetrinker haben weniger Körperfett und mehr Muskelmasse
Neue Studie: Wie alt wollen Menschen wirklich werden?
Forschungs-Feed
Direkt aus den Feeds von Journalen und Instituten, in Originalsprache. Die Relevanz kommt aus einem Stichwortfilter.
Diabetes drug metformin could be repurposed to help slow aging mechanisms
Metformin, a widely prescribed, safe and inexpensive drug for type 2 diabetes, is a first-line treatment that lowers blood sugar and improves the body's response to insulin. The drug appears to trick cells into sensing an energy shortage, similar to what happens during fasting or dieting. This activates a key cellular energy sensor called AMPK, which helps trigger cellular waste cleanup and supports cellular repair. Now, a recent review suggests metformin might also help counter some effects of aging.
Immune System Signatures Correlate with the Near Term Risk of Developing Atherosclerosis
Atherosclerosis is universal; everyone develops fatty atherosclerotic plaques in their arteries at some point, and to some degree. Plaques narrow blood vessels to impede blood flow, and rupture of unstable plaque causes heart attack, stroke, and embolism. It is the largest cause of human mortality, and at present the best that the medical community can do is to slow down plaque growth. Established therapies based on reducing the amount of cholesterol carried outward from the liver on low-density lipoprotein (LDL) particles produce something like a 15% mortality risk reduction at best, and do not regress plaque to any meaningful degree. Interestingly, the drivers of atherosclerosis are sufficiently complex and varied for there to be a few lucky people who exhibit 10% or more plaque regression […]
ImmunoBrain’s immune reset shows promise in Alzheimer’s
Nature Medicine publication and late-breaking data put ImmunoBrain’s checkpoint immunotherapy and its clean safety profile in the spotlight. While much of Alzheimer’s drug development chases the disease’s hallmark proteins directly, ImmunoBrain Checkpoint is making its case from a different angle entirely: strengthening the body’s own immune system so it can help protect and repair the […] The post ImmunoBrain’s immune reset shows promise in Alzheimer’s appeared first on Longevity.Technology.
Short-term environmental enrichment modulates brain region-specific redox responses in adolescent female mice
BackgroundEnvironmental enrichment (EE) is a non-pharmacological intervention known to enhance neuroplasticity and resilience. However, studies of EE on brain redox balance have focused predominantly on males and single regions, leaving the developing female brain and region-specific responses largely uncharacterized. This study investigated the effects of a three-week EE protocol on oxidative balance in the hippocampus, hypothalamus, and brainstem of adolescent female C57BL/6 mice.MethodsLipid peroxidation was measured by thiobarbituric acid reactive substances (TBARS), and protein oxidation by carbonyl content. The enzymatic antioxidant system was evaluated through the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST). Non-enzymatic antioxidant defenses included quantification of reduced glutathione (GSH), oxidized glutathione (GSSG), the GSH
A validated workflow for paired total and small RNA sequencing from low-input submandibular gland biopsy specimens in de novo Parkinson’s disease patients
Parkinson’s disease (PD) is characterized by progressive α-synuclein aggregation, yet the molecular mechanisms underlying this process remain incompletely understood. Transcriptomic analyses may provide important insights into the RNA-mediated regulation of PD pathogenesis, but studies of affected brain tissue are limited by the inaccessibility of living brain tissue and post-mortem RNA degradation. The submandibular gland (SMG), which exhibits α-synuclein pathology comparable to that of the substantia nigra, represents a clinically accessible peripheral tissue for investigating disease-associated transcriptomic alterations. However, ultrasound-guided core needle biopsy yields only a limited amount of tissue, making comprehensive RNA sequencing technically challenging. Here, we present and validate a workflow for paired total RNA and small RNA sequencing from low-input SMG biopsy specime
Short, Intense Exercise Elicits Beneficial Metabolic Changes
A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic health benefits [1]. Short and intense vs. […]
Scientists may have found a shortcut to calorie restriction’s anti-aging benefits
Moderate calorie restriction lowered an immune protein called C3 that appears to help drive chronic inflammation as the body ages. Blocking the same protein reduced age related inflammation in mice, raising the possibility that future treatments could mimic some benefits of calorie restriction without severe dieting.
What you eat before age 2 may affect your health 70 years later
Britain’s postwar sugar rationing created a rare natural experiment that let researchers examine how early sugar exposure might affect health decades later. People who experienced more rationing during their first 1,000 days had lower rates of several cancers and showed signs of slower biological aging. They were also still eating less sugar and maintaining healthier diets around age 50.
A Tougher Extracellular Matrix Strengthens Tendons in Rats
Researchers have found that an upstream promoter of two extracellular matrix proteins increases healing and strength capabilities in the tendons of rats. Tendon injuries in older people Previous research has […]
A major Alzheimer’s risk gene may shrink brain cells years before symptoms
Researchers have uncovered a possible reason why the Alzheimer’s risk gene APOE4 can disrupt the brain long before memory problems begin. In mice, APOE4 increased a protein called Nell2, shrinking neurons and making memory circuits unusually active. That early hyperactivity predicted worse memory later in life. Reducing Nell2 in adult mice reversed the abnormal changes, raising hopes for a new way to intervene before Alzheimer’s progresses.
This shark can live 400 years. Its eyes barely seem to age
Greenland sharks may live for 400 years without suffering the kind of retinal decline normally associated with aging. Researchers found healthy eye tissue and active proteins specially adapted for seeing blue light in the dim Arctic depths. DNA repair mechanisms may help keep their eyes functioning across centuries. The discovery could eventually offer new clues for protecting human vision as we age.
Citrus compound reverses some signs of liver aging in older mice
The liver is a jack-of-all-trades and a master of all. From removing harmful substances and secreting bile to metabolizing proteins, carbohydrates and fats and managing the immune system, the liver does it all. As we age, liver cells undergo major structural changes, making the body prone to metabolic liver diseases such as fatty liver and inflammation, which, over time, can increase the risk of liver cancer.
Biograph launches comprehensive women’s health program for preventive care
Biograph has launched a Women’s Health Program integrated into its Core and Black tier preventive care model to consolidate female-specific history, personalized hormone testing, comprehensive risk assessment, and tailored nutrition and exercise into longitudinal physician-led care. Research cited in the announcement found U.S. women had a life expectancy of 80 years in 2022, at least […] The post Biograph launches comprehensive women’s health program for preventive care appeared first on Longevity.Technology.
Can AI put the cell back together?
GenBio AI’s AIDO Cell links DNA, RNA, protein and cellular behavior – and remembers what’s already happened to the cell. GenBio AI has launched AIDO Cell, a virtual cell system designed to simulate human cellular behavior across multiple biological layers within a single computational environment – allowing researchers to perturb DNA, RNA or proteins and […] The post Can AI put the cell back together? appeared first on Longevity.Technology.
Viome acquires Circulate Health to add plasma exchange clinics
Viome announced that it has acquired Circulate Health, a provider of physician-guided therapeutic plasma exchange delivered outside the hospital setting. The transaction unites Viome’s molecular diagnostic and precision nutrition platform with Circulate’s nationwide clinical network of more than 200 partner clinics, the company said. Circulate’s protocols target healthspan and chronic disease and include a proprietary […] The post Viome acquires Circulate Health to add plasma exchange clinics appeared first on Longevity.Technology.
A little-known protein may be fueling Alzheimer’s — and scientists found a way to block it
An experimental Alzheimer’s compound prevented damaging protein clumps from forming in the brains of mice, helping nerve cells survive longer and reducing amyloid buildup. The treatment also appeared to improve heart health and slow some signs of aging, raising hopes for an entirely new way to combat dementia.
Immorta Bio maps out AI’s next move in longevity
Immorta Bio’s latest blueprint argues longevity may depend less on finding one magic marker and more on connecting every piece of the puzzle. For years, the hunt for longevity’s ‘holy grail’ has often centered on finding the one biological marker that reveals how fast we are really aging. A blood test, a protein, a molecule […] The post Immorta Bio maps out AI’s next move in longevity appeared first on Longevity.Technology.
Neuro Force One launches digital coaching platform and gut-health system
Neuro Force One appeared at the 2026 Texas High School Coaches Association Coaching School & Convention in Houston, introducing its NF1 Coaches & Teams Platform, NF1 mobile app and NF1 RESET, a three-part gut-health and nutritional-support system. The company offered participating schools complimentary one-year access to the NF1 Coaches & Teams Platform for entire athletic […] The post Neuro Force One launches digital coaching platform and gut-health system appeared first on Longevity.Technology.
Remedium raises $10m for adjustable gene therapy
Lilly joins Series A backing a platform designed to turn adipocytes into long-term, adjustable producers of therapeutic proteins. Remedium Bio has announced the initial close of a planned $10 million Series A financing, bringing new capital to its effort to develop durable, adjustable gene therapies for chronic disease. The round is led by Lifespan Vision […] The post Remedium raises $10m for adjustable gene therapy appeared first on Longevity.Technology.
Beyond protein: what really matters for healthy aging
As protein becomes the latest nutrition obsession, experts unpack what actually keeps us healthy as we age, from movement to food to habits. If you spend enough time online, it can start to feel as though healthy aging has been reduced to a single question: how much protein did you eat today? Protein bars have […] The post Beyond protein: what really matters for healthy aging appeared first on Longevity.Technology.
For decades, we were told to choose low-fat dairy. New research says otherwise
Full-fat dairy may be healthier than conventional advice has suggested. In a 12-week study, adults who ate three servings a day showed no meaningful increases in weight, body fat, cholesterol, or insulin resistance. They also experienced improved blood pressure and consumed more calcium, protein, and vitamin D. The findings suggest dairy’s complex structure may matter more than its saturated fat content alone.
Eating less protein could slow aging, major review finds
A sweeping review of more than 350 studies suggests that the protein boom may be overselling what many people actually need. Eating less protein appears to improve metabolism, reduce inflammation and cellular damage, and activate pathways linked to healthier aging and longer life.
Brain scans hint at new way to slow Alzheimer’s
New data suggest LM11A-31 may help preserve the brain’s communication networks, offering another promising path in Alzheimer’s research. The race against Alzheimer’s disease has largely revolved around amyloid plaques. The latest generation of FDA-approved drugs aims to clear these sticky protein deposits from the brain, slowing disease progression by removing what has long been viewed […] The post Brain scans hint at new way to slow Alzheimer’s appeared first on Longevity.Technology.
Is personalized nutrition worth it?
As personalized nutrition grows, experts argue the smartest health strategy may be simple: test first, supplement second. Walk into any health store or scroll through social media for five minutes and you’ll quickly get the impression that longevity comes in capsule form. Magnesium for sleep. Creatine for strength. Vitamin D for immunity. Electrolytes because your […] The post Is personalized nutrition worth it? appeared first on Longevity.Technology.
Nova Capital commits $100m to back UAE longevity platform
New UAE-backed venture bets future of longevity lies not in standalone wellness brands, but in building ecosystem people never have to leave. In the wellness industry, one app tracks your sleep, another counts your steps, a smartwatch nudges you to stand, your gym has its own membership, your nutrition advice comes from somewhere else and […] The post Nova Capital commits $100m to back UAE longevity platform appeared first on Longevity.Technology.
Intermittent fasting helped people keep weight off for a year
A 12-week intermittent fasting program produced weight-loss benefits that were still visible a year later. Participants who ate within an eight-hour window maintained more weight loss than those who followed their usual longer eating schedule. Both early and late eating windows worked, while early fasting appeared especially helpful for preserving fat loss.
Mediterranean diet may activate tiny proteins that protect the heart and brain
The Mediterranean diet may influence aging through tiny proteins produced inside the cell’s mitochondria. Older adults who followed the diet most closely had higher levels of humanin and SHMOOSE, which have been linked to heart and brain protection. Olive oil, fish, legumes, and fewer refined carbohydrates appeared especially important. The findings could eventually help scientists develop more personalized nutrition plans for healthy aging.
From lab to factory: Klotho reaches a new milestone
Avaí Bio completes a manufacturing step that could move one of longevity’s most-watched proteins closer to the clinic. The hardest part of longevity may be figuring out how to manufacture it. That idea feels especially timely after Avaí Bio announced it has completed a Good Manufacturing Practice (GMP) Master Cell Bank for its alpha-Klotho therapy […] The post From lab to factory: Klotho reaches a new milestone appeared first on Longevity.Technology.
Cognito’s sensory device shows potential to preserve brain wiring in early Alzheimer’s
Cognito Therapeutics presented exploratory cerebrospinal fluid proteomics data at AAIC 2026, according to the company. The poster, from the Phase 2 FLICKER study, evaluated daily Spectris sensory stimulation in amyloid-positive mild cognitive impairment participants and used unbiased, mass spectrometry-based proteomics to assess treatment-related changes. Investigators reported increased CSF levels of multiple HDL-like lipid transport proteins, […] The post Cognito’s sensory device shows potential to preserve brain wiring in early Alzheimer’s appeared first on Longevity.Technology.
Voyager’s single-dose Alzheimer’s treatment safely reduces brain tau protein in primates
At the Alzheimer’s Association International Conference in London, Voyager Therapeutics presented six-month GLP toxicology data showing a single intravenous dose of VY1706 was well tolerated and produced sustained tau protein reductions up to 75% in key brain regions of non-human primates over six months. The GLP study reported no adverse clinical pathology or histopathological findings […] The post Voyager’s single-dose Alzheimer’s treatment safely reduces brain tau protein in primates appeared first on Longevity.Technology.
Eisai’s experimental drug clears key Alzheimer’s brain protein by up to 90%
Eisai presented data at the Alzheimer’s Association International Conference (AAIC) 2026 showing that investigational anti-MTBR antibody etalanetug (E2814) reduced levels of the tau tangle-specific biomarker eMTBR-tau243 in people with dominantly inherited Alzheimer’s disease (DIAD). According to the company, etalanetug lowered cerebrospinal fluid eMTBR-tau243 by 62% at three months and 89% at nine months, and reduced […] The post Eisai’s experimental drug clears key Alzheimer’s brain protein by up to 90% appeared first on Longevity.Technology.
When irreversible no longer means forever
New study shows long-assumed irreversible AGEs can be removed from aged human tissue ex vivo – opening a new chapter in damage repair. For decades, researchers studying aging have largely viewed advanced glycation end products (AGEs) as part of biology’s accumulating baggage – chemical modifications that slowly build up on long-lived proteins and, once established, […] The post When irreversible no longer means forever appeared first on Longevity.Technology.
Alzheimer's tau protein has a surprising secret role in memory
Researchers found that tau is essential for turning new experiences into lasting memories by helping organize the brain's memory-storing cells. The mouse study also revealed how abnormal tau may contribute to Alzheimer's by disrupting both the formation of new memories and the recall of existing ones.
Scientists found a longevity diet that helped mice eat more and lose fat
Scientists found that a modified Mediterranean-style diet with low protein and just enough methionine helped mice live healthier lives while reducing body fat and frailty. Human data also linked lower animal protein intake to lower rates of obesity and Type 2 diabetes, suggesting the approach could benefit people as well.
Quellen: Lifespan Research Institute · Fight Aging! · Longevity.Technology · ScienceDaily – Healthy Aging · ScienceDaily – Nutrition · ScienceDaily – Fitness · Nature – Ageing · Frontiers in Aging Neuroscience · Medical Xpress – longevity · The Guardian – Health · Spektrum der Wissenschaft · Deutsches Ärzteblatt · Quarks · Index – Tudomány